Pharmacists realize several benefits from ePrescribing. First is patient safety. In the ePrescribing process, the details of the prescription are transmitted directly to the pharmacists, minimizing the possibility of human error. The provider types in the medication, dose, and quantity requested then it is transmitted directly. The ePrescribing software also incorporates a layer of protection by assessing the likelihood of drug interactions, allergies, and high doses. If the software detects any of the above inaccuracies, the provider will be alerted and is required to address the issue before the prescription is sent to the pharmacist. This feature in itself reduces the amount of rework required of pharmacists.

Pharmacists see a significant decrease in work that is put forth in an effort to get medications approved by health insurance companies. In the ePrescribing process, the patient's health insurance information is incorporated into the software itself. Therefore, the provider will be alerted to medications that are not covered by the patient's insurance company. Hence, a prescription will never be sent to a pharmacist if it is not covered by the patient's health insurance company. This is a great reduction of unnecessary work on the Pharmacists part.

Eprescribing essentially streamlines the entire process. Pharmacists benefit greatly because tasks that previously used to consume the majority of their day with redundant paperwork or follow-up calls, can now be spent on purposes that are more productive. Pharmacists can spend more time consulting with patients about their medications, compliant behavior, and possible side effects. Pharmacists will naturally continue to verify that patients are receiving accurate doses, and are free of drug interactions, but ultimately they can now perform at optimum efficiency and accuracy.

Hidden in this new concept of ePrescribing, is the fact that patients are inherently more compliant with filling their medications. Before the advent of ePrescribing, patients often neglected to actually fill their medications. Whether it was for financial reasons or pure non-compliance issues, patients simply did not fill every prescription that they received. Now, 11% more prescriptions are being filled and picked up by patients. Many ePrescribing software programs send providers daily notifications that alert them as to their patient's pharmacy pickup activity so that it can be logged in the patient's chart as well.